A common menstrual issue seen in women with Cushing's syndrome is?

In Cushing's syndrome, which is characterized by elevated levels of cortisol, a common menstrual issue observed is amenorrhea. This condition involves the absence of menstruation and is often linked to hormonal imbalances caused by excess cortisol. Cortisol can interfere with the normal regulatory mechanisms of the hypothalamic-pituitary-ovarian axis, which plays a crucial role in maintaining regular menstrual cycles.

In women with Cushing's syndrome, the hormonal disruptions may lead to alterations in ovarian function, resulting in diminished or absent menstrual periods. Understanding the impact of cortisol on the body’s hormonal regulation is crucial, particularly as it can lead to significant reproductive health issues, including amenorrhea.

Other options like hypermenorrhea, menorrhagia, and oligomenorrhea may occur in various other contexts but are not as frequently associated with Cushing's syndrome as amenorrhea is. Therefore, amenorrhea stands out as the correct answer in this context.