At what blood level does theophylline toxicity occur?

Theophylline toxicity is commonly associated with elevated blood levels of the drug, which can lead to significant and potentially life-threatening side effects. The therapeutic range for theophylline is typically between 10 to 20 mcg/mL; however, toxicity generally occurs when levels exceed 20 mcg/mL. At this concentration, patients may experience symptoms such as nausea, vomiting, palpitations, and seizures.

Therefore, the threshold for recognizing the onset of toxicity is primarily set at 20 mcg/mL. Levels above this not only indicate that the patient has surpassed the therapeutic window but also warrant immediate clinical attention and management to prevent severe complications. This understanding of theophylline levels is crucial for ensuring patient safety during treatment.