Can TPN be safely infused via a peripheral IV line for long durations?

Total Parenteral Nutrition (TPN) is a method of supplying nutrients directly into the bloodstream when a person cannot eat or absorb nutrients through their digestive tract. When considering the administration of TPN via peripheral intravenous (IV) lines, it is important to recognize the limitations and potential complications associated with this method.

Using a peripheral IV for TPN is not recommended for long durations because peripheral veins are smaller and more fragile than central veins, which increases the risk of complications such as phlebitis, infiltration, and thrombosis. TPN solutions are typically hypertonic and can irritate peripheral veins and lead to local adverse effects, making it unsuitable for sustained use. While it may be permissible to use for short periods, the formulation of TPN and the associated osmolarity make prolonged infusion via a peripheral line unsafe.

In contrast, central venous catheters are designed for long-term use and are preferred for TPN administration. They provide a larger volume for infusion and a more stable and safer route for the hypertonic solution that TPN presents. Overall, for optimal patient safety and to minimize complications, TPN should be administered via a central line rather than a peripheral IV line, thus justifying the answer that only allows for a