Cushing's syndrome can lead to which notable physical symptom?

Cushing's syndrome results from excessive levels of cortisol in the body and is associated with several distinctive physical symptoms. Puffiness of the face, often referred to as moon facies, is a common symptom as cortisol can cause fluid retention and changes in fat distribution. Additionally, thin skin and easy bruising are also notable characteristics due to the effects of cortisol on collagen synthesis, making the skin more fragile and prone to damage.

Both of these symptoms are significant because they reflect the underlying pathophysiology of cortisol's effect on the body. In contrast, soft skin with no striae does not align with the typical manifestations of Cushing's syndrome since patients often experience striae or stretch marks due to rapid skin expansion related to fat deposition and skin weakness caused by hormonal changes.