Griseofulvin is best administered with what type of meal?

Griseofulvin is an antifungal medication used predominantly to treat dermatophyte infections, such as ringworm. It is best administered with high-fat meals because the absorption of griseofulvin improves significantly in the presence of dietary fats. When taken alongside a meal rich in fat, the solubility of the medication increases, promoting better absorption in the gastrointestinal tract. This enhanced absorption is crucial for the drug to achieve effective blood levels and exert its antifungal effects.

In contrast, while griseofulvin can be taken with any meal or even light meals, these options do not provide the same benefit for optimal absorption. Vegetarian meals may lack sufficient fat content, and standard light meals may not include enough fat to improve griseofulvin's effectiveness. Hence, the specific instruction to take griseofulvin with a high-fat meal maximizes its therapeutic potential.