How does Cushing's syndrome affect a patient's resistance to infection?

Cushing's syndrome leads to decreased resistance to infection due to elevated levels of cortisol, which is a glucocorticoid hormone. In this condition, the excessive cortisol can impair the immune system's ability to respond effectively to pathogens. It interferes with the function of white blood cells, particularly lymphocytes, which are crucial for mounting an immune response. Additionally, cortisol can reduce the overall inflammatory response, which is necessary to fight infections.

Patients with Cushing's syndrome may find that they are more susceptible to infections such as pneumonia, herpes simplex, or fungal infections, among others. This increased vulnerability to infections is a significant clinical consideration for individuals diagnosed with Cushing's syndrome, highlighting the importance of monitoring and managing their health to prevent potential complications associated with infections.