How does Muscle weakness in Myasthenia Gravis respond to exercise?

Muscle weakness in Myasthenia Gravis tends to worsen with exercise due to the nature of the disorder itself. Myasthenia Gravis is an autoimmune condition in which antibodies attack the acetylcholine receptors at the neuromuscular junction, impairing the ability of nerves to communicate with muscles effectively.

During physical activity, the demand on the neuromuscular system increases, leading to greater fatigue because the impaired receptors can’t adequately transmit signals for muscle contraction. As a result, even minor exertion can lead to a decrease in muscle strength and greater weakness, reflecting the characteristic fluctuating nature of muscle strength in this condition.

It is important to recognize that the response to exercise can vary among individuals, but the general trend in those with Myasthenia Gravis is that exertion exacerbates weakness rather than alleviating it. Therefore, understanding that muscle strength deteriorates with activity is critical in managing this condition effectively.