In Cushing's syndrome, what change occurs to blood sugar levels?

In Cushing's syndrome, there is an increase in blood sugar levels. This condition is characterized by an overproduction of cortisol, a hormone produced by the adrenal glands. Cortisol plays a significant role in various metabolic processes, including the regulation of glucose.

Under normal circumstances, cortisol helps to increase blood sugar levels by promoting gluconeogenesis (the synthesis of glucose from non-carbohydrate sources) and decreasing the uptake of glucose by tissues, which ultimately leads to elevated blood sugar levels.

As a result of the excess cortisol in Cushing's syndrome, individuals typically experience hyperglycemia, which can sometimes lead to steroid-induced diabetes. This aspect of the syndrome is important for recognizing and managing potential complications, as well as for understanding the overall metabolic implications of having elevated cortisol levels.