Non-steroidal anti-inflammatory drugs should be administered how?

Administering non-steroidal anti-inflammatory drugs (NSAIDs) with food is essential to minimize gastrointestinal side effects. NSAIDs can irritate the stomach lining and increase the risk of ulcers and gastrointestinal bleeding. When taken with food, the presence of the food can help buffer the stomach acid and slow the absorption of the medication, reducing the risk of these adverse effects.

Taking NSAIDs on an empty stomach can lead to more intense irritation and discomfort, while the other options, such as taking them with lots of water or specifically before bedtime, do not provide the necessary protective effect on the stomach lining that food offers. Therefore, the recommendation to take NSAIDs with food is intended to enhance the safety and tolerability of these medications for the patient.