Rectal suppositories with an oil base should be...

Rectal suppositories with an oil base should be kept refrigerated to maintain their stability and integrity. The oil base can become unstable at higher room temperatures, potentially leading to melting or degradation of the suppository, which would affect its efficacy and safety when administered. Refrigeration helps to ensure that the suppository maintains its form and can be delivered effectively when needed.

Storing at room temperature may cause the suppository to soften or lose its intended structure, while warming before use may not provide the necessary benefits and could even lead to inconsistent dosing. Keeping them in a cool, dry place does not provide the specific low temperature needed for oil-based suppositories, making refrigeration the best practice for preserving their quality.