The major problem in cystic fibrosis is primarily due to which issue?

Cystic fibrosis is a genetic disorder that impacts the function of exocrine glands, which are responsible for producing mucus, sweat, and digestive juices. The fundamental issue in cystic fibrosis lies in the production of thick and sticky secretions due to a mutation in the CFTR gene. This leads to increased viscosity of the secretions, which in turn obstructs the airflow in the lungs and blocks the pancreatic ducts. As a result, this affects both respiratory and digestive functions, causing a variety of complications such as frequent lung infections and malabsorption of nutrients.

The severity of these issues highlights the importance of the thick mucus, which makes it difficult for the lungs to clear out bacteria and debris, leading to chronic infections and inflammation. The obstructions caused by this viscosity significantly contribute to the morbidity associated with cystic fibrosis, making this aspect the primary concern in managing the condition. Understanding this underlying mechanism is key for developing therapies aimed at alleviating symptoms and improving quality of life for patients.