What class of drugs is commonly used as the first-line treatment for hypertension?

The commonly accepted first-line treatment for hypertension is diuretics, particularly thiazide diuretics. This class of medications works by promoting the elimination of sodium and water from the body, which effectively reduces blood volume and consequently lowers blood pressure. Thiazide diuretics have been extensively studied and are known for their efficacy in managing hypertension, especially in the initial stages of treatment.

These drugs are often favored due to their ability to not only lower blood pressure but also to reduce the risk of cardiovascular events. They are often well-tolerated in many patients and can be less costly compared to some alternative classes of antihypertensives.

While other classes of medications, such as beta-blockers, ACE inhibitors, and calcium channel blockers, are also effective for treating high blood pressure, they are typically not considered first-line options unless there are specific clinical reasons or comorbidities that necessitate their use. The recommendation for diuretics as the initial therapy is based on extensive clinical guidelines and research supporting their use in managing hypertension safely and effectively.