What condition is associated with the over secretion of the adrenal cortex?

Cushing's syndrome is specifically linked to the over secretion of hormones from the adrenal cortex, particularly cortisol. This condition can arise from various causes, including tumors of the adrenal glands or pituitary gland, leading to excess production of adrenocorticotropic hormone (ACTH). The excess cortisol can result in a range of clinical symptoms such as weight gain, hypertension, hyperglycemia, and characteristic changes in physical appearance, including a rounded face and increased fat deposition around the abdomen.

In contrast, Addison's disease is associated with insufficient production of adrenal hormones, particularly cortisol and aldosterone, leading to symptoms like fatigue, weight loss, and low blood pressure. Pheochromocytoma refers to a tumor of the adrenal gland that leads to excessive secretion of catecholamines (like adrenaline), causing symptoms like palpitations and hypertension, but does not primarily involve adrenal cortex hormones. Myxedema is related to severe hypothyroidism and is not associated with adrenal hormones at all. Each of these conditions involves different pathways and physiological changes, reinforcing why Cushing's syndrome is the clear answer related to adrenal cortex over secretion.