What distinctive facial appearance do patients with Cushing's syndrome typically develop?

Patients with Cushing's syndrome typically develop a round or moon-shaped face due to the excessive levels of cortisol hormone in the body. This condition often leads to the accumulation of fat in specific areas, most notably in the face, neck, and trunk, which contributes to the characteristic rounded appearance. This change in facial structure occurs because hormonal imbalances can stimulate fat deposition, causing a fullness in the cheeks and jawline that gives the face a "moon" shape.

Recognizing this unique facial characteristic is crucial in clinical practice as it helps in the early identification of Cushing's syndrome, prompting further investigation and management of the underlying causes.