What is the common clinical manifestation of muscle weakness in Myasthenia Gravis?

In Myasthenia Gravis, the hallmark clinical manifestation is muscle weakness that typically worsens with activity and improves with rest. This condition is characterized by an autoimmune attack on acetylcholine receptors at the neuromuscular junction, leading to inefficient communication between nerve and muscle. As a result, patients experience pronounced fatigue after periods of exertion, making it a key symptom to identify.

Muscle weakness may present in various muscle groups, often affecting eye movements, facial expressions, and the limbs. Patients may report that their strength decreases during repetitive tasks, which can lead to significant fatigue and hinder daily activities. Therefore, the common clinical manifestation of fatigue in conjunction with muscle weakness is a classic presentation in individuals suffering from Myasthenia Gravis, making this the correct answer.