What is the expected outcome for red blood cells exposed to Hgb S?

The expected outcome for red blood cells exposed to Hemoglobin S (Hgb S) is that they become crescent-shaped and rigid. This change occurs in conditions such as sickle cell disease, where normal hemoglobin is replaced with Hgb S. Under low oxygen conditions, Hgb S molecules polymerize, causing the red blood cells to assume a distinctive sickle or crescent shape.

These sickled cells are less flexible than normal red blood cells, making it difficult for them to navigate through small blood vessels. This can lead to blockages, pain, and various complications associated with sickle cell disease. The rigidity and abnormal shape also make these cells more prone to hemolysis, although complete disintegration of the cells is not a typical outcome specifically from exposure to Hgb S.

The other options do not accurately reflect the physiological changes that occur when red blood cells are exposed to Hgb S. Understanding this transformation process is crucial in recognizing the complications that arise from sickle cell disease and the nature of hemoglobin disorders.