What is the maximum duration for safely infusing TPN via a peripheral IV line?

The maximum duration for safely infusing total parenteral nutrition (TPN) via a peripheral IV line is generally up to 48 to 72 hours. This is due to several factors, including the risk of irritation and potential phlebitis associated with peripheral lines, especially when infusing concentrated solutions like TPN, which can significantly damage the vein's endothelial lining.

Using a peripheral IV for TPN is typically a short-term solution because of these risk factors. Over time, prolonged use can compromise the integrity of the vein and lead to complications. In contrast, when patients require long-term TPN, central venous access is preferred to reduce these risks and allow for a more stable and continuous nutritional support plan. Therefore, the 48 to 72 hours guideline accurately reflects the safety window for TPN administration via peripheral IV, emphasizing the importance of adhering to this recommendation to ensure patient safety and minimize adverse effects.