What role does bilirubin play in the symptoms of hepatitis?

In the context of hepatitis, bilirubin plays a significant role in the manifestation of symptoms primarily due to its accumulation in the bloodstream. When the liver is inflamed or damaged, as seen in hepatitis, it becomes less efficient at processing and excreting bilirubin, which is a breakdown product of hemoglobin from red blood cells.

As bilirubin levels increase, it results in jaundice, which is characterized by the yellowing of the skin and the sclera of the eyes. Jaundice occurs because the excess bilirubin deposits in tissues. In addition to jaundice, the accumulation of bilirubin can also lead to pruritus, or itching, as the high levels of this substance can irritate the skin.

These symptoms are direct consequences of the liver’s inability to effectively clear bilirubin due to the underlying hepatic dysfunction associated with conditions like hepatitis. Thus, option C accurately captures the connection between bilirubin, jaundice, and pruritus in the context of hepatitis.