What shape do red blood cells (RBCs) take when influenced by Hgb S?

Prepare for the Mark Klimek Blue Book Part 1 Exam. Study with multiple choice questions, flashcards, and comprehensive explanations. Get ready for your nursing exam!

Red blood cells (RBCs) influenced by hemoglobin S (Hgb S) adopt a crescent shape, also known as a sickle shape, particularly under low oxygen conditions. This characteristic shape is most notably observed in individuals who have sickle cell disease. The deformation occurs due to the polymerization of deoxygenated hemoglobin S, leading to a rigid structure that can obstruct blood flow and cause various complications.

Understanding this transformation is critical in recognizing how sickle cell disease affects circulation and oxygen delivery in the body. In contrast, the alternative shapes mentioned do not accurately represent the morphology of RBCs affected by Hgb S. Regular RBCs, influenced by normal hemoglobin, typically maintain a biconcave disc shape which allows for efficient gas exchange, while the terms round, spindle-shaped, or any other shapes are not associated with the pathological changes seen in sickle cell anemia.

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