Where does syphilis first infect the body?

Syphilis begins its infection in the body primarily through mucous membranes. The bacterium responsible for syphilis, Treponema pallidum, typically enters the body during sexual contact, specifically through small breaks or lesions in the mucous membranes found in the genital region, anus, or mouth. This site of entry is crucial as it is where the initial interaction with the immune system occurs, facilitating the bacteria's penetration and subsequent spread.

The mucous membranes are particularly vulnerable due to their moist, delicate nature, allowing the bacteria to infiltrate easily. Once the bacteria have entered through these membranes, they can spread through the bloodstream to various parts of the body, leading to systemic infection. Understanding this entry point is essential for recognizing how syphilis can be transmitted and the factors contributing to its spread.