Which of the following is NOT a commonly used medication for herpes?

The medication that is not commonly used for herpes is Prednisone. Acyclovir, Valacyclovir, and Famciclovir are antiviral drugs specifically developed to treat infections caused by certain types of viruses, including the herpes simplex virus and the varicella-zoster virus, which causes shingles.

Prednisone, on the other hand, is a corticosteroid that is primarily used to reduce inflammation and suppress the immune system. It does not target viral infections directly. While it may be used in some scenarios to manage the inflammation caused by herpes or other conditions, it is not an antiviral medication, nor is it effective in treating herpes outbreaks. Thus, it does not have a direct role in managing herpes viral infections, making it the correct choice for this question.