Which side effect is commonly associated with the use of Vincristine?

Vincristine is known to commonly cause constipation as a side effect. This is primarily due to its action as a vinca alkaloid that interferes with microtubule formation, which impacts various bodily functions, including those of the gastrointestinal tract. As the drug affects neuronal signals, it can lead to decreased peristalsis and slower bowel movement, resulting in constipation.

Other side effects associated with Vincristine include peripheral neuropathy and alopecia, but constipation is specifically notable and frequently reported by patients undergoing treatment with this medication. Understanding the side effects of chemotherapeutic agents is crucial for managing patient care effectively, especially in anticipating and addressing symptoms that may arise during treatment.