Which symptom is exacerbated by activity in a patient with Myasthenia Gravis?

In Myasthenia Gravis, the hallmark symptom that worsens with physical activity is muscle weakness. This autoimmune disorder impacts the communication between nerves and muscles, specifically at the neuromuscular junction, leading to fluctuating muscle strength. The weakness typically becomes more pronounced with exertion and may improve with rest.

As the patient engages in physical activity, there is an increased demand for neuromuscular transmission, which the damaged receptors cannot meet due to the body's immune response. This results in a more significant decline in muscle strength, making it a defining feature of the condition. By recognizing that muscle weakness exacerbates with activity, caregivers and clinicians can better provide supportive measures and tailor treatment plans to enhance the quality of life for those affected by Myasthenia Gravis.