Which symptom typically follows the right upper quadrant pain in appendicitis?

In the context of appendicitis, pain often begins in the periumbilical region but typically migrates to the right lower quadrant, where the appendix is located. Following this shift in pain, nausea and vomiting commonly occur. This is due to the irritation of the gastrointestinal tract and surrounding structures caused by inflammation.

Nausea and vomiting result from the body's response to visceral pain and irritation, which triggers the autonomic nervous system's response, leading to these gastrointestinal symptoms. The presence of nausea and vomiting is a classic symptom of appendicitis, marking the progression of the condition and indicating potential complications such as perforation if left untreated.

Other symptoms like loss of appetite, fever, and severe headache can also accompany appendicitis, but the characteristic nausea and vomiting directly correlates with the evolving nature of the abdominal symptoms and demonstrates the body's reaction to the inflammation of the appendix.